Statistical confidence estimation for Hi-C data reveals regulatory chromatin contacts
نویسندگان
چکیده
منابع مشابه
Statistical confidence estimation for Hi-C data reveals regulatory chromatin contacts.
Our current understanding of how DNA is packed in the nucleus is most accurate at the fine scale of individual nucleosomes and at the large scale of chromosome territories. However, accurate modeling of DNA architecture at the intermediate scale of ∼50 kb-10 Mb is crucial for identifying functional interactions among regulatory elements and their target promoters. We describe a method, Fit-Hi-C...
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The sequence of a genome is insufficient to understand all genomic processes carried out in the cell nucleus. To achieve this, the knowledge of its three-dimensional architecture is necessary. Advances in genomic technologies and the development of new analytical methods, such as Chromosome Conformation Capture (3C) and its derivatives, provide unprecedented insights in the spatial organization...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2014
ISSN: 1088-9051
DOI: 10.1101/gr.160374.113